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The Gonal-f® RFF Pen is preloaded with medication and ready to use; there's no mixing, no loading of cartridges.

Simple and Reliable Dosing
The Gonal-f® RFF Pen dosing adjusts with a turn of the dial, making it easy to inject your precise medication dose for every injection prescribed.

Precision You Can See
The Gonal-f® RFF Pen has a visual confirmation scale that lets you know the precise dose you set is ready to inject, reducing the chance of dosing errors. The Gonal-f® RFF Pen is the only ready-to-use FSH pen available in three, multiple-dose presentations.

Important Considerations: Gonal-f® RFF Pen can cause serious side effects including ovarian hyperstimulation syndrome (OHSS), with or without lung or blood vessel problems, and multiple births.

The most common side effects observed with the use of the Gonal-f® RFF Pen may include headache, stomach pain, stomach bloating, OHSS and nausea. Bruising, pain and redness can happen at the injection site. For complete product details, see the Full Prescribing Information.

You should review with your Fertility Specialist the risks and benefits of using the Gonal-f® RFF Pen. As with any medication, report any and all side effects, symptoms or physical changes to your healthcare provider.


Gonal-f® RFF (follitropin alfa for injection) is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the á- and â-subunits. The á- and â-subunits have 92 and 111 amino acids, respectively, and their primary and tertiary structure are indistinguishable from those of human follicle stimulating hormone. Recombinant FSH production occurs in genetically modified Chinese Hamster Ovary (CHO) cells cultured in bioreactors. Purification by immunochromatography using an antibody specifically binding FSH results in a highly purified preparation with a consistent FSH isoform profile, and a high specific activity. The biological activity of follitropin alfa is determined by measuring the increase in ovary weight in female rats. The in vivo biological activity of follitropin alfa has been calibrated against the first International Standard for recombinant human follicle stimulating hormone established in 1995 by the Expert Committee on Biological Standards of the World Health Organization. Gonal-f® RFF contains no luteinizing hormone (LH) activity. Based on available data derived from physico-chemical tests and bioassays, follitropin alfa and follitropin beta, another recombinant follicle stimulating hormone product, are indistinguishable.

Gonal-f® RFF is a sterile, lyophilized powder intended for subcutaneous injection after reconstitution.


Under current storage conditions, Gonal-f® RFF may contain up to 10% of oxidized follitropin alfa.

Therapeutic Class: Infertility